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Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. [6] For the prevention of cardiovascular disease, statins are a first-line treatment. [ 6 ]
Type 2 statins all exist in their active hydroxy-acid forms. Fluvastatin has indole ring structure, while atorvastatin and rosuvastatin have pyrrole and pyrimidine based ring structure respectively. The lipophilic cerivastatin has a pyridine-based ring structure. [citation needed]
Bruce D. Roth is an American organic and medicinal chemist who trained at Saint Joseph's College, Iowa State University and the University of Rochester, and, at the age of 32, discovered atorvastatin, the statin-class drug sold as Lipitor that would become the largest-selling drug in pharmaceutical history (as of 2003).
Cholesterol synthesis appears to ... Due to patent expiration, most of the block-buster branded statins have been generic since 2012, including atorvastatin, the ...
AstraZeneca (AZN) shares surged late in the session Tuesday, closing at $48.74, up $4.02, just shy of 9%. What makes a Big Pharma stock jump so much, especially on a day markets skidded some 3%?
Aldol structural units are found in many important molecules, whether naturally occurring or synthetic. [8] [9] The reaction is well used on an industrial scale, notably of pentaerythritol, [10] trimethylolpropane, the plasticizer precursor 2-ethylhexanol, and the drug Lipitor (atorvastatin, calcium salt). [11]
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The company's first international move took it to Russia in 1992. There, Dr. Reddy's formed a joint venture with the country's biggest pharmaceuticals producer, Biomed.They pulled out in 1995 amid accusations of scandal, involving "a significant material loss due to the activities of Moscow's branch of Reddy's Labs with the help of Biomed's chief executive". [8]