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The cat is monitored frequently during the first few months of treatment; The cat eats a diet low in carbohydrates and high in protein. Cats may present with type 2 (insulin-resistant) diabetes, at least at first, but hyperglycemia and amyloidosis, left untreated, will damage the pancreas over time and progress to insulin-dependent diabetes.
The normal lifespan of domestic cats is in the range of 13 to 20 years. As cats senesce, they undergo predictable changes in health and behavior. Dental disease and loss of olfaction are common as cats age, affecting eating habits. Arthritis and sarcopenia are also common in older cats.
Feline disease refers to infections or illnesses that affect cats. They may cause symptoms, sickness or the death of the animal. Some diseases are symptomatic in one cat but asymptomatic in others. Feline diseases are often opportunistic and tend to be more serious in cats that already have concurrent sicknesses.
Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. [ 1 ] [ 2 ] It is used together with a diabetic diet and exercise.
Arthritis may hinder a cat's ability to get into the litter box in time. Night-time vocalizing is relatively common in hyperthyroid cats or cats with hypertension, which can also cause retinal detachment and blindness, leading to anxiety and confusion. Progressively painful periodontal disease can discourage the cat from visiting its food bowl ...
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Dangerous side effects from the injectable canine drug Librela — used to treat osteoarthritis joint pain — have been linked to seizures, lameness and loss of muscle control, the FDA warned.
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
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