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Organophosphate poisoning is poisoning due to organophosphates ... For example, methyl parathion is ... neurotoxicity, kidney/liver damage, and birth defects ...
Organophosphate-induced delayed neuropathy (OPIDN), also called organophosphate-induced delayed polyneuropathy (OPIDP), is a neuropathy caused by killing of neurons in the central nervous system, especially in the spinal cord, as a result of acute or chronic organophosphate poisoning.
Organophosphates are best known for their use as pesticides. Like most functional groups, organophosphates occur in a diverse range of forms, [2] with important examples including key biomolecules such as DNA, RNA and ATP, as well as many insecticides, herbicides, nerve agents and flame retardants.
Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. [1] It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant – alters the normal activity of the nervous system in such a ...
VX is an extremely toxic synthetic chemical compound in the organophosphorus class, specifically, a thiophosphonate.In the class of nerve agents, it was developed for military use in chemical warfare after translation of earlier discoveries of organophosphate toxicity in pesticide research.
Common mnemonics for the symptomatology of organophosphate poisoning, including sarin, are the "killer Bs" of bronchorrhea and bronchospasm because they are the leading cause of death, [8] and SLUDGE – salivation, lacrimation, urination, defecation, gastrointestinal distress, and emesis (vomiting). Death may follow in one to ten minutes after ...
Tiny pieces of plastic have been discovered in the human placenta, breastmilk, testes, liver, kidneys, carotid arteries and the brain. - Douglas Sacha/Moment RF/Getty Images/File
When toxicants bind to AChE, they inhibit the breakdown of ACh. This results in continued nerve impulses across the synapses, which eventually cause nerve system damage. Examples of AChE inhibitors are organophosphates and carbamates, which are components found in pesticides (see Acetylcholinesterase inhibitors). Irritants.