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The most common chemotherapy used for B-cell non-Hodgkin lymphoma is R-CHOP, which is a regimen of four drugs (cyclophosphamide, doxorubicin, vincristine, and prednisone) plus rituximab. [ 33 ] R-CHP with polatuzumab vedotin , an antibody-drug conjugate, was included as a category 1 preferred regimen for first-line DLBCL by the National ...
In the United States there has been an increase in the 5-year relative survival rate between people diagnosed with cancer in 1975-1977 (48.9%) and people diagnosed with cancer in 2007-2013 (69.2%); these figures coincide with a 20% decrease in cancer mortality from 1950 to 2014. [8]
Hodgkin lymphoma typically is treated with radiotherapy alone, as long as it is localized. [59] Advanced Hodgkin disease requires systemic chemotherapy, sometimes combined with radiotherapy. [60] Chemotherapy used includes the ABVD regimen, which is commonly used in the United States.
Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. For these regimens, in general, a better toxicity profile is expected. [6]: 55–59 All chemotherapy regimens require that the recipient be capable of undergoing the treatment.
Radiation and some chemotherapy drugs, however, increase the risk of other cancers, heart disease, or lung disease over the subsequent decades. [9] In 2015, about 574,000 people globally had Hodgkin lymphoma, and 23,900 (4.2%) died. [6] [7] In the United States, 0.2% of people are affected at some point in their life. [5]
Because of the prolonged survival, which was typically about 10 years in past decades, but which can extend to a normal life expectancy, the prevalence (number of people living with the disease) is much higher than the incidence (new diagnoses). [2] CLL is the most common type of leukemia in the UK, accounting for 38% of all leukemia cases.
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. [1] Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. [1]
Burkitt lymphoma is a very aggressive cancer, which can quickly metastasize and spread throughout the body if the cancer is not treated quickly. If the patient is left untreated, or if treatment is initiated too late, Burkitt lymphoma can be fatal. [4] Burkitt lymphoma in children often has a better prognosis than the same cancer in an adult.
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