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Wikiversity:Diagram of the pathways of human steroidogenesis Polski: Enzymy biorące udział w steroidogenezie. Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.
The outermost layer, the zona glomerulosa is the main site for the production of aldosterone, a mineralocorticoid. The synthesis and secretion of aldosterone are mainly regulated by the renin–angiotensin–aldosterone system. The zona glomerulosa cells express a specific enzyme aldosterone synthase (also known as CYP11B2).
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Aldosterone is responsible for the reabsorption of about 2% of filtered sodium in the kidneys, which is nearly equal to the entire sodium content in human blood under normal glomerular filtration rates. [19] Aldosterone, probably acting through mineralocorticoid receptors, may positively influence neurogenesis in the dentate gyrus. [20]
18-Hydroxylase (aldosterone synthase) – mineralocorticoid synthesis; 21-Hydroxylase – corticosteroid synthesis; Cytochrome P450 (CYP1, 2, 3) – estrogen metabolism; Hydroxysteroid dehydrogenases (and ketosteroid reductases) 3α-Hydroxysteroid dehydrogenase – androgen, progestogen, and neurosteroid synthesis and metabolism
The enzyme aldosterone synthase (also known as CYP11B2) acts in this location [3] [4] The expression of neuron-specific proteins in the zona glomerulosa cells of human adrenocortical tissues has been predicted and reported by several authors [5] [6] [7] and it was suggested that the expression of proteins like the neuronal cell adhesion ...
Skeletal formula of aldosterone. Created using ACD/ChemSketch 10.0, Inkscape, and vim. Date: 4 October 2008: Source: Vector version of Aldosterone-2D-skeletal.png. Author: Aldosterone-2D-skeletal.png by Ben Mills, vectorized by Fvasconcellos (talk · contribs) Permission (Reusing this file)
The fetal zone produces large amounts of adrenal androgens (male sex hormones) that are used by the placenta for estrogen biosynthesis. [39] Cortical development of the adrenal gland is regulated mostly by ACTH , a hormone produced by the pituitary gland that stimulates cortisol synthesis. [ 40 ]