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A derivative of trifluorotoluene, 3-aminobenzotrifluoride, is the precursor to the herbicide fluometuron. [3] It is synthesized via nitration followed by reduction to meta-H 2 NC 6 H 4 CF 3. This aniline is then converted to the urea. Flumetramide (6-[4-(trifluoromethyl)phenyl]morpholin-3-one), a skeletal muscle relaxant, is also prepared from ...
Benzonitrile is the chemical compound with the formula C 6 H 5 (CN), abbreviated PhCN. This aromatic organic compound is a colorless liquid with a sweet bitter almond odour. It is mainly used as a precursor to the resin benzoguanamine .
Substituent Name (in approximate order of deactivating strength) Structure Type of electronic effect Directing effect Strong trifluoromethylsulfonyl group [13]-SO 2 CF 3 –I, –M meta (substituted) ammonium groups [14]-NR 3 + (R = alkyl or H) –I nitro group-NO 2 –I, –M sulfonic acids and sulfonyl groups-SO 3 H, -SO 2 R cyano group-C≡N
Typical nitrile ligands are acetonitrile, propionitrile, and benzonitrile.The structures of [Ru(NH 3) 5 (NCPh)] n+ have been determined for the 2+ and 3+ oxidation states. Upon oxidation the Ru-NH 3 distances contract and the Ru-NCPh distances elongate, consistent with amines serving as pure-sigma donor ligands and nitriles functioning as pi-acceptors.
The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H 3 C – CF 3, and hexafluoroacetone F 3 C –CO– CF 3.
19 F NMR chemical shifts in the literature vary strongly, commonly by over 1 ppm, even within the same solvent. [5] Although the reference compound for 19 F NMR spectroscopy, neat CFCl 3 (0 ppm), [6] has been used since the 1950s, [7] clear instructions on how to measure and deploy it in routine measurements were not present until recently. [5]
Thiazyl fluoride, NSF, is a colourless, pungent gas at room temperature and condenses to a pale yellow liquid at 0.4 °C. [1] Along with thiazyl trifluoride, NSF 3, it is an important precursor to sulfur-nitrogen-fluorine compounds. It is notable for its extreme hygroscopicity.
The first to investigate trifluoromethyl groups in relationship to biological activity was F. Lehmann in 1927. [5] An early review appeared in 1958. [6] An early synthetic method was developed by Frédéric Swarts in 1892, [7] based on antimony fluoride. In this reaction benzotrichloride was reacted with SbF 3 to form PhCF 2 Cl and PhCF 3.