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Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus bacterium of the genus Bordetella, and the causative agent of pertussis or whooping cough. Its virulence factors include pertussis toxin , adenylate cyclase toxin , filamentous haemagglutinin , pertactin , fimbria , and tracheal cytotoxin .
A bacterium, Bordetella pertussis, is able to escape the immune response by inhibiting neutrophils and macrophages from invading the infection site early on. [4] One cause of antigenic escape is that a pathogen's epitopes (the binding sites for immune cells ) become too similar to a person's naturally occurring MHC-1 epitopes, resulting in the ...
Is the virus mutating? In 2019, researchers at the CDC found the bacteria that causes pertussis — bacterium Bordetella pertussis — has changed over time, which could make the current vaccines ...
Adenylate cyclase toxin from Bordetella pertussis is a 1706 amino acid residue long protein.The protein consists of three domains: from the N-terminus up to roughly residue 400, there is an adenylate-cyclase domain; between residues 500 and 700, there is a hydrophobic domain; and from residue 1000 to the C-terminus, there are calcium binding repeats.
Pavia explains that whooping cough is caused by bacteria called Bordetella pertussis, and a closely related relative, called Bordetella parapertussis.
The CDC explained on its website that it "is a highly contagious respiratory disease caused by the bacterium Bordetella pertussis. ... Whooping cough is also known as "Pertussis."
Adenylate cyclase toxin (CyaA) is released from bacterium Bordetella pertussis by the T1SS (Type 1 secretion system) and released in the host’s respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. [1] CyaA plays a particular role in the early phases of airway colonization.
Whooping cough, also called pertussis, is highly contagious and most common in babies, but children and adults can get infected as well, according to Cleveland Clinic.
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related to: bacterium bordetella pertussis mutating- 114 W 3rd Ave, Columbus, OH · Directions · (614) 456-1108
