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Maternal serum AFP (MSAFP) varies by orders of magnitude during the course of a normal pregnancy. MSAFP increases rapidly until about 32 weeks gestation, then decreases gradually. After the pregnancy ends it decreases rapidly, with a half-life of about 5 days. Typically, MSAFP is measured in the beginning of the second trimester (14–16 weeks).
174 11576 Ensembl ENSG00000081051 ENSMUSG00000054932 UniProt P02771 P02772 RefSeq (mRNA) NM_001134 NM_001354717 NM_007423 RefSeq (protein) NP_001125 NP_001341646 NP_031449 Location (UCSC) Chr 4: 73.43 – 73.46 Mb Chr 5: 90.64 – 90.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Alpha-fetoprotein (AFP, α-fetoprotein ; also sometimes called alpha-1-fetoprotein, alpha ...
Having multiple gestations, such as twins, increases MSAFP because each fetus secretes its own AFP Incorrect estimation of gestational age is the most common cause of abnormal MSAFP levels An example of an algorithm for indications for further testing depending on the outcome of non-genetic blood tests including the triple test.
A multiple of the median (MoM) is a measure of how far an individual test result deviates from the median.MoM is commonly used to report the results of medical screening tests, particularly where the results of the individual tests are highly variable.
MSAFP/quad. screen (four simultaneous blood tests) (maternal serum AFP, inhibin A, estriol, and βHCG) – elevations, low numbers or odd patterns correlate with neural tube defect risk and increased risks of trisomy 18 or trisomy 21 [17] Ultrasound either abdominal or transvaginal to assess cervix, placenta, fluid and baby [18]
Oligohydramnios is a medical condition in pregnancy characterized by a deficiency of amniotic fluid, the fluid that surrounds the fetus in the abdomen, in the amniotic sac.
An elevated MSAFP measured at 16–18 weeks gestation is a good predictor of open neural tube defects, however the test has a very high false positive rate, (2% of all women tested in Ontario, Canada between 1993 and 2000 tested positive without having an open neural tube defect, although 5% is the commonly quoted result worldwide) and only a ...
Newborn screening programs initially used screening criteria based largely on criteria established by JMG Wilson and F. Jungner in 1968. [6] Although not specifically about newborn population screening programs, their publication, Principles and practice of screening for disease proposed ten criteria that screening programs should meet before being used as a public health measure.