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In 2009, she published research that showed the mole rat's cells expressed a gene called p16 which prevented tumours from developing. [6] As a result of their "pioneering research on the causes of cancer resistance in naked mole-rats," Gorbunova and Seluanov won the 2009 Cozzarelli Prize. [ 7 ]
However, although these naked mole rats are mammalian, they are highly atypical in terms of aging studies and may not serve as the best model for humans. For example, naked mole rats have a disproportionately high longevity quotient and live in eusocial societies, where breeding is usually designated to a queen. [46]
The Golan Heights blind mole-rat (Spalax golani) and the Judean Mountains blind mole-rat (Spalax judaei) are also resistant to cancer, but by a different mechanism. [ 35 ] In July 2023 a study reported the transference of the gene responsible for HMW-HA from a naked mole rat to mice leading to improved health and an approximate 4.4 percent ...
Gene Annotator: The Gene Annotator or GA tool takes as input a list of gene symbols, RGD IDs, GenBank accession numbers, Ensembl identifiers, or a chromosomal region and retrieves gene orthologs, external database identifiers and ontology annotations for the corresponding genes in RGD. The data can be downloaded into an Excel spreadsheet or ...
The Expression Atlas allows searches by gene, splice variant, protein attribute, disease, treatment or organism part (cell types/tissues). Individual genes or gene sets can be searched for. All datasets in Expression Atlas have its metadata manually curated and its data analysed through standardised analysis pipelines.
The maximum life spans of mice, naked mole-rats and humans are respectively ~3, ~30 and ~129 years. [65] Of these, the shortest lived species, mouse, expresses DNA repair genes, including core genes in several DNA repair pathways, at a lower level than do humans and naked mole rats. [ 65 ]
SPOILERS BELOW—do not scroll any further if you don't want the answer revealed. The New York Times. Today's Wordle Answer for #1301 on Friday, January 10, 2025.
Usually living in harsh or limiting environments, these mole-rats aid in raising siblings and relatives born to a single reproductive queen. However, this classification is controversial owing to disputed definitions of 'eusociality'. To avoid inbreeding, mole rats sometimes outbreed and establish new colonies when resources are sufficient. [42]