Search results
Results from the WOW.Com Content Network
Certain amines and alkaloids, including such drugs as morphine, and curare alkaloids, can displace histamine in granules and cause its release. Antibiotics like polymyxin are also found to stimulate histamine release. Histamine release occurs when allergens bind to mast-cell-bound IgE antibodies.
Vitamin A deficiency, for example, causes an increase in inflammatory responses, [38] and anti-inflammatory drugs work specifically by inhibiting the enzymes that produce inflammatory eicosanoids. Additionally, certain illicit drugs such as cocaine and ecstasy may exert some of their detrimental effects by activating transcription factors ...
Histamine is a weak base (a compound able to react with a hydrogen ion to form an acid) that can link with acid groups within the granules of the mast cells. [8] The mechanism of the displacement theory. The crux of this theory lies in the assumption that histamine liberators release histamine by displacing it from cells.
The C3a, C4a and C5a components are referred to as anaphylatoxins: [4] [5] they cause smooth muscle contraction, vasodilation, histamine release from mast cells, and enhanced vascular permeability. [5] They also mediate chemotaxis, inflammation, and generation of cytotoxic oxygen radicals. [5]
Histamine can cause bladder inflammation and contribute to the symptoms of such bladder diseases as cystitis (inflammation of the bladder) or painful bladder disease. Histamine binds to H 2 receptors in the bladder smooth muscle, leading to relaxation [contradictory] of the bladder muscle and promotion of urine storage. Histamine does not seem ...
Mast cell stabilizers inhibit the release of allergic and inflammatory mediators, helping to prevent and treat allergic conditions. They work by blocking a calcium channel which is essential for mast cell degranulation , [ 21 ] inhibiting the release of histamine and other mediators from mast cells.
In immunology, cytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs. [3] It refers to cytokine storm syndromes (CSS) [ 4 ] and occurs when large numbers of white blood cells are activated and release inflammatory cytokines ...
Some medications, like opioids and certain other drugs, induce urticaria by directly acting on mast cells, triggering histamine release. [2] Non-steroidal anti-inflammatory drugs (NSAIDs) contribute uniquely to urticaria by inhibiting the COX-1 pathway, leading to increased production of leukotrienes, vasodilators implicated in edema and ...