Search results
Results from the WOW.Com Content Network
An endocrinology study by Garcia-Falgueras and Swaab postulated that "In humans, the main mechanism responsible of sexual identity and orientation involves a direct effect of testosterone on the developing brain." [1]: 25 Further, their study puts forward that intrauterine exposure to hormones is largely determinative. Sketching the argument ...
Cefazolin, also known as cefazoline and cephazolin, is a first-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. [2] Specifically it is used to treat cellulitis , urinary tract infections , pneumonia , endocarditis , joint infection , and biliary tract infections . [ 2 ]
The progestogens are named for their function in maintaining pregnancy (i.e., progestational), although they are also present at other phases of the estrous and menstrual cycles. [2] [3] The progestogens are one of three types of sex hormones, the others being estrogens like estradiol and androgens/anabolic steroids like testosterone.
The discovery of the backdoor pathway to DHT biosynthesis in tammar wallaby pouch young prompted research into identifying and characterizing similar pathways in humans, leading to a better understanding of the regulation, metabolism, and therapeutic targeting of androgen biosynthesis in human health and diseases related to excessive or ...
In mice, prenatal testosterone transfer causes higher blood concentrations of testosterone in 2M females when compared to 1M or 0M females. [6] This has a variety of consequences on later female behavior, physiology, and morphology. Below is a table comparing physiological, morphological, and behavioral differences of 0M and 2M female mice. [1]
In general, pregnane derivatives (e.g., progesterone, dydrogesterone, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate) do not virilize even in high dose; testosterone derivatives (ethisterone) and 19-nortestosterone (norethisterone, norethisterone acetate, etc.) generally virilize, but there are exceptions (e.g., noretynodrel, allylestrenol) that do not.
The androgenic activity of androgenic progestins is mediated by two mechanisms: 1) direct binding to and activation of the androgen receptor; and 2) displacement of testosterone from sex hormone-binding globulin (SHBG), thereby increasing free (and thus bioactive) testosterone levels. [230]
Androgens (including testosterone and dihydrotestosterone) inhibit monoamine oxidase (MAO) in the pineal gland, leading to increased melatonin and reduced LH and FSH by melatonin-induced increase of Gonadotropin-Inhibitory Hormone (GnIH) [21] synthesis and secretion. Testosterone can also be aromatized into estradiol (E2) to inhibit LH. E2 ...