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MGUS is a relatively stable condition afflicting 3% of people aged 50 and 5% of people aged 70; it progresses to multiple myeloma at a rate of 0.5–1% cases per year; smoldering multiple myeloma does so at a rate of 10% per year for the first 5 years, but then falls off sharply to 3% per year for the next 5 years and thereafter to 1% per year.
Multiple myeloma is usually diagnosed because malignant plasma cells continue to produce an antibody that can be ... [5] Prognosis: Median survival of 13.8 years. [8]
Older age at diagnosis and treatment resulted in published reports of median survival of approximately 5 years from diagnosis. [4] Currently, median survival is 6.5 years. [77] In rare instances, Waldenström macroglobulinemia progresses to multiple myeloma. [78]
Average five-year survival in the United States after being diagnosed with bone and joint cancer is 67%. [5] The earliest known bone tumor was an osteosarcoma in a foot bone discovered in South Africa, between 1.6 and 1.8 million years ago. [6]
Most cases of SPB progress to multiple myeloma within 2–4 years of diagnosis, but the overall median survival for SPB is 7–12 years. 30–50% of extramedullary plasmacytoma cases progress to multiple myeloma with a median time of 1.5–2.5 years. 15–45% of SPB and 50–65% of extramedullary plasmacytoma are disease free after 10 years. [3]
Overall median survival was 8.12 years with survival decreasing with age from 12.4 years for patients <40 to 5.2 years for patients of 60 years or older. [34] Risk of its recurrence or progression to overt multiple myeloma within 3 years is ~10%.
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