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Recurrent herpes of the eye is caused by reactivation of the virus in a latently infected sensory ganglion, transport of the virus down the nerve axon to sensory nerve endings, and subsequent infection of ocular surface. The following classification of herpes simplex keratitis is important for understanding this disease:
Lytic infection is sometimes known as "productive" infection. Latent cells harbor the virus for long time periods, then occasionally convert to productive infection which may lead to a recurrence of symptomatic Herpes symptoms. During latency, most of the Herpes DNA is inactive, with the exception of LAT, which accumulates within infected cells.
Herpes simplex virions. Herpes simplex virus 1 and 2 (HSV 1 and HSV 2) are part of the alpha subfamily of herpesviruses. The lytic phase of infection occurs within mucoepithelial cells while the latent infection of these cells occurs in neurons. These two viruses are the cause of oral and genital herpes. [4]
Site of Latency Means of Spread HHV‑1: Herpes simplex virus-1 (HSV-1) α (Alpha) Mucoepithelial: Oral and/or genital herpes, herpetic gingivostomatitis, pharyngitis, eczema herpeticum, herpetic whitlow, herpes simplex keratitis, erythema multiforme, encephalitis, as well as other herpes simplex infections: Neuron (sensory ganglia)
Similar to other herpesviridae, the herpes simplex viruses establish latent lifelong infection, and thus cannot be eradicated from the body with current treatments. [ 63 ] Treatment usually involves general-purpose antiviral drugs that interfere with viral replication, reduce the physical severity of outbreak-associated lesions, and lower the ...
Visceral herpes simplex infection; Cytomegalovirus (CMV) infection (retinitis or of an organ other than the liver, spleen or lymph nodes) Any disseminated mycosis (e.g. histoplasmosis, coccidioidomycosis, penicilliosis) Recurrent non-typhoidal salmonella sepsis; Lymphoma (cerebral or B cell non-Hodgkin) Invasive cervical carcinoma; Visceral ...
Herpes simplex, often known simply as herpes, is a viral infection caused by the herpes simplex virus. [5] Herpes infections are categorized by the area of the body that is infected. The two major types of herpes are oral herpes and genital herpes, though other forms also exist. Oral herpes involves the face or mouth.
Acute retinal necrosis (ARN) [1] is a medical inflammatory condition of the eye. [2] The condition presents itself as a necrotizing retinitis. [3] The inflammation onset is due to certain herpes viruses, varicella zoster virus (VZV), herpes simplex virus (HSV-1 and HSV-2) and Epstein–Barr virus (EBV).
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