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Liothyronine is a manufactured form of the thyroid hormone triiodothyronine (T 3). [2] It is most commonly used to treat hypothyroidism and myxedema coma . [ 2 ] It can be taken by mouth or by injection into a vein .
In these cases, synthetic liothyronine is preferred due to the potential differences between the natural thyroid products. Some studies show that the mixed therapy is beneficial to all patients, but the addition of lyothyronine contains additional side effects and the medication should be evaluated on an individual basis. [ 27 ]
Each 64.8 mg (one grain) of thyroid extract contains approximately 38 μg and 9 μg of measurable levothyroxine (T4) and liothyronine (T3), respectively. [1] Arguments against desiccated thyroid include: Desiccated thyroid preparations have a greater variability from batch to batch than synthetic ones. [9]
Levothyroxine, also known as L-thyroxine, is a synthetic form of the thyroid hormone thyroxine (T 4). [5] [8] It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma. [5]
T 3 is the more metabolically active hormone produced from T 4.T 4 is deiodinated by three deiodinase enzymes to produce the more-active triiodothyronine: . Type I present in liver, kidney, thyroid, and (to a lesser extent) pituitary; it accounts for 80% of the deiodination of T 4.
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The addition of liothyronine should be regarded as experimental, initially only for a trial period of 3 months, and in a set ratio to the current dose of levothyroxine. [68] The guideline explicitly aims to enhance the safety of this approach and to counter its indiscriminate use.
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