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Ethyl bromodifluoroacetate is an ester with the chemical formula F 2 Br C H−CO 2 CH 2 CH 3. It can be used to introduce the CF 2 group when synthesising chemical compounds. It is a colorless to yellow liquid. It is an ethyl ester of bromodifluoroacetic acid.
Phenylboronic acid or benzeneboronic acid, abbreviated as PhB(OH) 2 where Ph is the phenyl group C 6 H 5 - and B(OH) 2 is a boronic acid containing a phenyl substituent and two hydroxyl groups attached to boron. Phenylboronic acid is a white powder and is commonly used in organic synthesis.
Sodium iodide is soluble in acetone while sodium chloride and sodium bromide are not; [3] therefore, the reaction is driven toward products by mass action due to the precipitation of the poorly soluble NaCl or NaBr. An example involves the conversion of the ethyl ester of 5-bromovaleric acid to the iodide: [4]
Under ideal conditions the reaction produces 50% of both the alcohol and the carboxylic acid (it takes two aldehydes to produce one acid and one alcohol). [5] This can be economically viable if the products can be separated and both have a value; the commercial conversion of furfural into furfuryl alcohol and 2-furoic acid is an example of this ...
Mix the protected carbamate to be deprotected with 3 M hydrochloric acid (HCl) in ethyl acetate for 30 min at ambient temperature [16] Heat the carbamate in a mixture of aqueous hydrochloric acid and toluene at 65 °C [17] Dissolving desired protected compound in a 50/50 mix of dichloromethane and trifluoroacetic acid [18]
A reaction modification with an aromatic phenyl ester as a reactant is called the Fries rearrangement. In the Scholl reaction two arenes couple directly (sometimes called Friedel–Crafts arylation). [22] In the Blanc chloromethylation a chloromethyl group is added to an arene with formaldehyde, hydrochloric acid and zinc chloride.
Bromoacetic acid is the chemical compound with the formula Br C H 2 CO 2 H. This colorless solid is a relatively strong alkylating agent . Bromoacetic acid and its esters are widely used building blocks in organic synthesis , for example, in pharmaceutical chemistry .
Most primary and secondary perfluoroalcohols are unstable, for example trifluoromethanol eliminates hydrogen fluoride, forming carbonyl fluoride. [2] This reaction is reversible. [3] CF 3 OH → COF 2 + HF. Stable perfluorinated alcohols include nonafluoro-tert-butyl alcohol ((CF 3) 3 COH) and pentafluorophenol (C 6 F 5 OH).