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The theory of the velocity of the transmission of the pulse through the circulation dates back to 1808 with the work of Thomas Young. [9] The relationship between pulse wave velocity (PWV) and arterial wall stiffness can be derived from Newton's second law of motion (=) applied to a small fluid element, where the force on the element equals the product of density (the mass per unit volume ...
Arterial stiffness occurs as a consequence of biological aging, arteriosclerosis and genetic disorders, such as Marfan, Williams, and Ehlers-Danlos syndromes. [1] Inflammation plays a major role in arteriosclerosis and arterial stiffness. [ 2 ]
The arterial resistivity index (also called as Resistance index, abbreviated as RI), developed by Léandre Pourcelot , is a measure of pulsatile blood flow that reflects the resistance to blood flow caused by microvascular bed distal to the site of measurement.
The lumped parameter model consists in a system of ordinary differential equations that adhere to the principles of conservation of mass and momentum balance. The model is obtained exploiting the electrical analogy where the current represents the blood flow, the voltage represents the pressure difference, the electric resistance plays the role of the vascular resistance (determined by the ...
Distensibility is a metric of the stiffness of blood vessels. It is defined as = ...
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Compliance diminishes with age and menopause. Arterial compliance is measured by ultrasound as a pressure (carotid artery) and volume (outflow into aorta) relationship. [5] Compliance, in simple terms, is the degree to which a container experiences pressure or force without disruption. It is used as an indication of arterial stiffness.
Afterload is the mean tension produced by a chamber of the heart in order to contract. It can also be considered as the ‘load’ that the heart must eject blood against. Afterload is, therefore, a consequence of aortic large vessel compliance, wave reflection, and small vessel resistance (LV afterload) or similar pulmonary artery parameters (RV afterload