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Spironolactone is one of the acne treatments included in the American Academy of Dermatology treatment guidelines. The drug isn’t generally used as a so-called first-line treatment for acne.
Spironolactone is an acne treatment prescribed by dermatologists. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more.
Spironolactone: Spironolactone is ... More research is needed on its effectiveness, but limited research shows some promise. ... Also important to know: Most acne treatments typically take at ...
Spironolactone may be more effective than birth control pills in the treatment of acne, and the combination of spironolactone with a birth control pill may have greater effectiveness for acne than either alone. [85] In addition, some clinical research has found that flutamide is more effective than spironolactone in the treatment of acne. [64]
The AR antagonism of spironolactone mostly underlies its antiandrogenic activity and is the major mechanism responsible for its therapeutic benefits in the treatment of androgen-dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women.
The effectiveness of spironolactone for acne appears to be dose-dependent. [117] High-dose cyproterone acetate alone reportedly decreases acne symptoms in women by 75 to 90% within three months. [128] It is usually combined with an estrogen to avoid menstrual irregularities and estrogen deficiency. [129]
The best ways to treat and prevent hormonal acne. There are several different treatment options that can help you get rid of hormonal acne, but you should start by talking to a dermatologist about ...
Side effects of spironolactone in clinical studies for acne in women Side effect RCTs Tooltip Randomized controlled trials (n (ITT Tooltip Intention-to-treat analysis) = 326) Case series (n (ITT Tooltip Intention-to-treat analysis) = 663) Number % Number % Menstrual irregularities: 38: 13.4 (of 283) 216: 33.4 (of 646) Breast tenderness: 8: 2.5: ...
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