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The low demands of thermogenesis mean that free fatty acids draw, for the most part, on lipolysis as the method of energy production. A comprehensive list of human and mouse genes regulating cold-induced thermogenesis (CIT) in living animals or tissue samples has been assembled [15] and is available in CITGeneDB. [16]
The human body has two methods of thermogenesis, which produces heat to raise the core body temperature. The first is shivering, which occurs in an unclothed person when the ambient air temperature is under 25 °C (77 °F) [dubious – discuss]. [18] It is limited by the amount of glycogen available in the body. [5]
As in other mammals, human thermoregulation is an important aspect of homeostasis. In thermoregulation, body heat is generated mostly in the deep organs, especially the liver, brain, and heart, and in contraction of skeletal muscles. [1] Humans have been able to adapt to a great diversity of climates, including hot humid and hot arid.
Starvation response in animals (including humans) is a set of adaptive biochemical and physiological changes, triggered by lack of food or extreme weight loss, in which the body seeks to conserve energy by reducing metabolic rate and/or non-resting energy expenditure to prolong survival and preserve body fat and lean mass.
Shivering (also called shuddering) is a bodily function in response to cold and extreme fear in warm-blooded animals. When the core body temperature drops, the shivering reflex is triggered to maintain homeostasis. Skeletal muscles begin to shake in small movements, creating warmth by expending energy.
Its primary function is thermoregulation. In addition to heat produced by shivering muscle, brown adipose tissue produces heat by non-shivering thermogenesis. The therapeutic targeting of brown fat for the treatment of human obesity is an active research field. [10] [11]
Thermogenic means tending to produce heat, and the term is commonly applied to drugs which increase heat through metabolic stimulation, [1] or to microorganisms which create heat within organic waste. Approximately all enzymatic reaction in the human body is thermogenic, which gives rise to the basal metabolic rate. [2]
While UCP1 plays a key thermogenic role in wide range placental mammals, particularly those with small body size and those that hibernate, the UCP1 gene has lost functionality in several large-bodied lineages (e.g. horses, elephants, sea cows, whales and hyraxes) and lineages with low metabolic rates (e.g. pangolins, armadillos, sloths and ...