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If the drug distributes into all body water the volume of distribution would increase to approximately = 0.57 L/kg [8] If the drug readily diffuses into the body fat the volume of distribution may increase dramatically, an example is chloroquine which has a V D = {\displaystyle V_{D}=} 250-302 L/kg [ 9 ]
The ED50 is commonly used as a measure of the reasonable expectancy of a drug effect, but does not necessarily represent the dose that a clinician might use. This depends on the need for the effect, and also the toxicity. The toxicity and even the lethality of a drug can be quantified by the TD 50 and LD 50 respectively. Ideally, the effective ...
Typically, blood flow velocities in the common carotid artery are measured as peak systolic velocity (PSV) and end diastolic velocity (EDV). In a study of normative men aged 20-29 years, the average PSV was 115 cm/sec and EDV was 32 cm/sec. In men 80 years and older, the average PSV was 88 cm/sec and EDV was 17 cm/sec. [7]
In cardiovascular physiology, stroke volume (SV) is the volume of blood pumped from the ventricle per beat. Stroke volume is calculated using measurements of ventricle volumes from an echocardiogram and subtracting the volume of the blood in the ventricle at the end of a beat (called end-systolic volume [note 1]) from the volume of blood just prior to the beat (called end-diastolic volume).
The AUC (from zero to infinity) represents the total drug exposure across time. AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure. Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic ...
Because greater EDVs cause greater distention of the ventricle, EDV is often used synonymously with preload, which refers to the length of the sarcomeres in cardiac muscle prior to contraction . An increase in EDV increases the preload on the heart and, through the Frank-Starling mechanism of the heart, increases the amount of blood ejected ...
Cardiovascular agents are drugs used to treat diseases associated with the heart or blood vessels. These medications are available for purchase only with a physician’s prescription . They include, but are not limited to, drugs that target hypertension ( antihypertensives ), hyperlipidemia ( antihyperlipidemics ) and blood clotting (blood ...