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Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors. [32] [33] By binding to the NMDA receptor with a higher affinity than Mg 2+ ions, memantine is able to inhibit the prolonged influx of Ca 2+ ions, particularly from extrasynaptic receptors, which forms the basis of neuronal excitotoxicity.
Memantine (Namenda) - treats Dementia and Alzheimer's. N. Neurontin – an anticonvulsant which is sometimes used as a mood stabilizer, anti-anxiety agent or to ...
The -NH 2 group on memantine, which is protonated under physiological pH of the body, represents the region that binds at or near to the Mg 2+ site. [18] Adding two methyl groups to the -N on the memantine structure has shown to decrease affinity, giving an IC 50 value of (28.4+1.4) μM.
Memantine/donepezil, sold under the brand name Namzaric among others, is a fixed dose combination medication used for the treatment of dementia of the Alzheimer's type. [1] It contains memantine , as the hydrochloride, a NMDA receptor antagonist ; and donepezil as the hydrochloride, an acetylcholinesterase inhibitor . [ 1 ]
Cuba closed schools and told non-essential workers to stay home on Friday as its electrical grid faltered following the failure of a major power plant, causing widespread blackouts across the ...
[36] [38] The specific degrees of inhibition after 4 weeks were 99.4% with 10 mg/day, 99.5% with 5 mg/day, 96.0% with 10 mg twice per week, and 75.9% with 10 mg once per week, respectively. [38] On the basis of these findings, it was concluded that 20 mg per week (as 10 mg twice per week) is the minimum dosage that can produce maximal and long ...
At doses under 20 mg/day, selegiline is a selective and irreversible inhibitor of monoamine oxidase B (MAO-B), increasing levels of dopamine in the brain. In clinical trials, Selegiline has been used in the treatment of attention deficit hyperactivity disorder (ADHD). [107]
Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not glia, observed in restricted brain regions of rats and certain other animal models exposed to large quantities of psychoactive drugs that inhibit the normal operation of the neuronal NMDA receptor.