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P. aeruginosa is a Gram-negative, aerobic (and at times facultatively anaerobic), rod-shaped bacterium with unipolar motility. [80] It has been identified as an opportunistic pathogen of both humans and plants. [81] P. aeruginosa is the type species of the genus Pseudomonas. [82]
Many of these plants are used intentionally as psychoactive drugs, for medicinal, religious, and/or recreational purposes. Some have been used ritually as entheogens for millennia. [1] [2] The plants are listed according to the specific psychoactive chemical substances they contain; many contain multiple known psychoactive compounds.
Effective against aerobic bacteria (not obligate/facultative anaerobes) and tularemia. All aminoglycosides are ineffective when taken orally as the stomach will digest the drug before it goes into the bloodstream. However aminoglycosides are effective in Intravenous, intramuscular and topical forms. Hearing loss; Vertigo; Kidney damage
In these cases it is often used in combination with metronidazole, which provides coverage for anaerobic pathogens. [7] complicated urinary tract infections, including acute pyelonephritis, in adults. hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. [11]
Entheogenic drugs and the archaeological record; Hallucinogenic fish; List of plants used for smoking; List of psychoactive substances and precursor chemicals derived from genetically modified organisms; List of psychoactive substances derived from artificial fungi biotransformation; List of substances used in rituals; Medicinal fungi
Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria. [3] Streptomycin is the first-in-class aminoglycoside antibiotic.
In China, Japan, India, and Germany, there is a great deal of interest in and support for the search for new drugs from higher plants. [4] For example, the Herbalome Project was launched in China in 2008 and aims to use high throughput sequencing and toxicity testing to identify active components in traditional herbal remedies.
Monobactams exert their antibacterial effects by binding to penicillin-binding proteins (PBPs), thereby inhibiting bacterial wall synthesis. [5] Monobactams exhibit poor affinity for PBPs of Gram-positive bacteria as well as of strictly anaerobic bacteria, resulting in a lack of significant antimicrobial activity against these kinds of organisms. [3]