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The hippocampus plays an important role in the transfer of information from short-term memory to long-term memory during encoding and retrieval stages. These stages do not need to occur successively, but are, as studies seem to indicate, and they are broadly divided in the neuronal mechanisms that they require or even in the hippocampal areas ...
In Alzheimer's disease (and other forms of dementia), the hippocampus is one of the first regions of the brain to suffer damage; [6] short-term memory loss and disorientation are included among the early symptoms.
Alzheimer's disease (AD) ... The disease is known to target the hippocampus which is associated with memory, and this is responsible for the first symptoms of memory ...
The hippocampal neuronal cell loss and gliosis are disproportionate to the Alzheimer's disease "neuropathological change in the same section." [13] One sided hippocampal sclerosis has a 40-50% prevalence even when the TDP-43 inclusions involve both sides of the brain.
Using an Alzheimer’s mouse model, they found that blocking the enzyme, called indoleamine-2,3-dioxygenase 1, or IDO1, helped preserve memory and cognition in the early stages of the disease.
Lopez et al. [16] have shown, in a multimodal study, that there are differences in the volume of the left entorhinal cortex between progressing (to Alzheimer's disease) and stable mild cognitive impairment patients. These authors also found that the volume of the left entorhinal cortex inversely correlates with the level of alpha band phase ...
Around 70% of these cases are likely to be Alzheimer’s disease, the most common form of dementia. ... These reduced inflammatory effects were most notable in the hippocampus — the area of the ...
Scientists initially identified memory loss associated with aging as an early manifestation of Alzheimer's; however, more recent evidence suggests that a distinct process affects the dentate gyrus (DG), which is a subregion of the hippocampus, and causes memory deterioration. [5]
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