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Vitamin B 12 is absorbed by a B 12-specific transport proteins or via passive diffusion. [12] Transport-mediated absorption and tissue delivery is a complex process involving three transport proteins: haptocorrin (HC), intrinsic factor (IF) and transcobalamin II (TC2), and respective membrane receptor proteins. HC is present in saliva.
The Schilling test has multiple stages. [3] As noted below, it can be done at any time after vitamin B 12 supplementation and body store replacement, and some clinicians recommend that in severe deficiency cases, at least several weeks of vitamin repletion be done before the test (more than one B 12 shot, and also oral folic acid), in order to ensure that impaired absorption of B 12 (with or ...
Because vitamin B 12 absorption is a multistep process that involves the stomach, pancreas and small intestine, and is mediated by two carriers: Haptocorrin and intrinsic factor, and because Haptocorrin (transcobalamin I) binds to vitamin B 12, and Vitamin B 12 is acid-sensitive, when vitamin B 12 binds to Haptocorrin it can safely pass through ...
Everyone requires a certain amount of B12 depending on their age, starting with .5 mcg per day for infants up to 2.4 mcg for teens and adults and even more—2.6 mcg and 2.8 mcg, respectively, for ...
6947 n/a Ensembl ENSG00000134827 n/a UniProt P20061 n/a RefSeq (mRNA) NM_001062 n/a RefSeq (protein) NP_001053 n/a Location (UCSC) Chr 11: 59.85 – 59.87 Mb n/a PubMed search n/a Wikidata View/Edit Human Haptocorrin (HC) also known as transcobalamin-1 (TC-1) or cobalophilin is a transcobalamin protein that in humans is encoded by the TCN1 gene. One essential function of haptocorrin is ...
Adults need about 2.4 micrograms of B12 a day (that much can be found in one portion of salmon, canned tuna or ground beef), with pregnant and nursing women needing slightly more (2.6 and 2.8 mcg ...
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