Search results
Results from the WOW.Com Content Network
The majority of drug-related deaths involve misuse of heroin or other opioids in combination with benzodiazepines or other CNS depressant drugs. In most cases of fatal overdose it is likely that lack of opioid tolerance combined with the depressant effects of benzodiazepines is the cause of death.
Risk factors for opioid overdose include opioid dependence, injecting opioids, using high doses of opioids, and use together with alcohol, benzodiazepines, or cocaine. [1] [2] The risk is particularly high following detoxification. [1] Dependence on prescription opioids can occur from their use to treat chronic pain. [1]
The combination is crushed together and insufflated Belladonna: Hashish: Alamout black hash [5] Mixed Caffeine: Cannabis: Hippie-speedball [16] [17] Hippie-speedballing Caffeine: Diphenhydramine: Sleep walk Sleepwalking Caffeine: Methamphetamine: Ya ba, biker's coffee, kamikaze Cacao bean: Magic mushroom: Aztec use of entheogens.
Combining these two drugs together not only increases a person's risk of the aforementioned adverse effects, but can increase a person's risk of overdose and death. [111] Benzodiazepines are also the second leading cause of teen overdose death after fentanyl. They killed 152 people in 2021, less than a fifth of fentanyl's death toll. [112]
Benzodiazepines can cause death when mixed with other CNS depressants such as opioids, alcohol, or barbiturates. [ 7 ] [ 8 ] [ 9 ] GHB combined with alcohol can lead to a long-lasting coma-like state (‘G-sleep’) or even accidental death, particularly in light of GHB's narrow threshold for overdose.
Mixing opioids with another depressant, such as benzodiazepines or alcohol, increases the chance of an overdose and respiratory depression. Opioid overdose causes a decreased level of consciousness, pinpoint pupils, and respiratory depression. Other symptoms include seizures and muscle spasms.
Finally, note that the benzodiazepine core is a privileged scaffold, which has been used to derive drugs with diverse activity that is not limited to the GABA A modulatory action of the classical benzodiazepines, [60] such as devazepide and tifluadom, however these have not been included in the list below. 2,3-benzodiazepines such as tofisopam ...
Although prescriptions for nimetazepam have decreased, abuse of the drug is still significant in Brunei, Singapore, Malaysia, and the Philippines. It is commonly used in combination with methamphetamine and MDMA (Ecstasy) and opiates (especially heroin or morphine). The strict legal restrictions nimetazepam is subject to in Malaysia has made ...