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Molecular imprinting is a technique to create template-shaped cavities in polymer matrices with predetermined selectivity and high affinity. [1] This technique is based on the system used by enzymes for substrate recognition, which is called the "lock and key" model.
A molecularly imprinted polymer (MIP) is a polymer that has been processed using the molecular imprinting technique which leaves cavities in the polymer matrix with an affinity for a chosen "template" molecule. The process usually involves initiating the polymerization of monomers in the presence of a template molecule that is extracted ...
Sergey introduced computational design into the field of molecular imprinting, by scientifically demonstrating that non-covalent interaction between the template molecule and polymer is through the technique known as 'bite and switch' wherein functional groups first non-covalently bond with the binding site, but during the rebinding step, the ...
As shown above, nanosensors with molecular imprinting technique are capable of selectively detecting ultrasensitive chemical species in that by artificially modifying the polymer matrices, molecular imprinting increases the affinity and selectivity. [12] Although molecularly imprinted polymers provide advantages in selective molecular ...
Molecularly imprinted polymer, polymers processed using the molecular imprinting technique with affinity to a chosen 'template molecule' Moon Impact Probe, of the Indian lunar satellite Chandrayaan-1; Model Intercomparison Project; see Coupled model intercomparison project; MIP, an interactive proof system complexity class; see Interactive ...
It is also a potentially simple and inexpensive technique. However, a lingering barrier to nanometer-scale patterning is the current reliance on other lithography techniques to generate the template. It is possible that self-assembled structures will provide the ultimate solution for templates of periodic patterns at scales of 10 nm and less. [36]
Negative selection through replica plating to screen for ampicillin sensitive colonies. Replica plating is a microbiological technique in which one or more secondary Petri plates containing different solid (agar-based) selective growth media (lacking nutrients or containing chemical growth inhibitors such as antibiotics) are inoculated with the same colonies of microorganisms from a primary ...
Klaus Hermann Mosbach (26 November 1932 – 22 January 2024) was a Swedish applied biochemist based at Lund University.He founded the Center for Molecular Imprinting in Lund, Sweden and was co-founder of the Institute of biotechnology at ETH Zurich Switzerland 1982.