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Drug delivery systems, lipid-[18] or polymer-based nanoparticles, can be designed to improve the pharmacokinetics and biodistribution of the drug. [ 19 ] [ 20 ] [ 21 ] However, the pharmacokinetics and pharmacodynamics of nanomedicine is highly variable among different patients. [ 22 ]
Reduction Sensitive Nanoparticles are used as nanomedicines for drug delivery. As nanocarriers, RSNP can be loaded with drugs for disease therapeutics. [ 18 ] This is commonly observed in the use of tumor and cancer treatments.
Polymer biodegradability is an important aspect to consider when choosing the appropriate nanoparticle chemistry. Nanocarriers composed of biodegradable polymers undergo hydrolysis in the body, producing biocompatible small molecules such as lactic acid and glycolic acid. [ 15 ]
Polymeric nanoparticles may also contain beneficial controlled release mechanisms. Polymer Branch. Nanoparticles made from natural polymers that are biodegradable have the abilities to target specific organs and tissues in the body, to carry DNA for gene therapy, and to deliver larger molecules such as proteins, peptides, and even genes. [7]
Polymer-protein hybrids are a class of nanostructure composed of protein-polymer conjugates (i.e. complexes composed of one protein attached to one or more polymer chains). [1] [2] The protein component generally gives the advantages of biocompatibility and biodegradability, as many proteins are produced naturally by the body and are therefore well tolerated and metabolized. [3]
In polymer chemistry, in situ polymerization is a preparation method that occurs "in the polymerization mixture" and is used to develop polymer nanocomposites from nanoparticles. There are numerous unstable oligomers ( molecules ) which must be synthesized in situ (i.e. in the reaction mixture but cannot be isolated on their own) for use in ...
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