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Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease , gastroesophageal reflux disease , and Zollinger-Ellison syndrome . [ 4 ]
It is able to cross the blood–brain barrier and can produce effects in the central nervous system (e.g., headaches, dizziness, somnolence). [2] The volume of distribution of cimetidine is 0.8 L/kg in adults and 1.2 to 2.1 L/kg in children. [6] Its plasma protein binding is 13 to 25% and is said to be without pharmacological significance.
In infants, acid suppression therapy is frequently prescribed to treat symptomatic gastroesophageal reflux in otherwise healthy infants (that is: without gastroesophageal reflux disease). A study from 2019 showed that PPI use alone and together with histamine H2-receptor antagonists was associated with an increased bone fracture hazard, which ...
Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer side effects, but other H 2 blockers famotidine and nizatidine have no CYP450 significant interactions. [ 131 ] Ranitidine was introduced in 1981, and was the world's biggest-selling prescription drug by 1987. [ 132 ]
Today, it is one of the oldest and most established intelligence measures of young children. Once the leading infant intelligence measure from the 1930s through the 1960s, the Gesell Developmental Schedule was nothing short of a breakthrough in infant ability testing when it was first constructed- the first of its kind, actually. [1] [3]
December 14, 2024 at 2:00 PM Donald Trump, George Stephanopoulos The settlement was publicly filed Saturday, just days before the two sides were set to sit for depositions in the case.
Donald Trump mocked Canadian Prime Minister Justin Trudeau after his top minister’s surprise resignation following a clash on how to handle the president-elect’s looming tariffs.
Infants are usually born weighing between 5 pounds 8 ounces (2,500 g) and 8 pounds 13 ounces (4,000 g), but infants born prematurely often weigh less. [ 17 ] Newborns typically lose 7–10% of their birth weight in the first few days, but they usually regain it within two weeks.