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  2. Management of heart failure - Wikipedia

    en.wikipedia.org/wiki/Management_of_heart_failure

    Sleep apnea is an under-recognized risk factor for heart failure. Uncontrolled sleep apnea may increase the risk of heart failure by up to 140%. [4] Weight reduction – through physical activity and dietary modification, as obesity is a risk factor for heart failure and left ventricular hypertrophy. Effective weight management has been shown ...

  3. Cardiac contractility modulation - Wikipedia

    en.wikipedia.org/wiki/Cardiac_contractility...

    The FDA approved the OPTIMIZER Smart System, which delivers cardiac contractility modulation therapy, as indicated to improve 6-minute hall walk distance, quality of life, and functional status of NYHA Class III heart failure patients who remain symptomatic despite guideline directed medical therapy, who are in normal sinus rhythm, are not indicated for cardiac resynchronization therapy, and ...

  4. RALES (trial) - Wikipedia

    en.wikipedia.org/wiki/RALES_(trial)

    The Randomized Aldactone Evaluation Study (RALES) trial is a landmark clinical study that assessed the impact of spironolactone, an aldosterone antagonist, on morbidity and mortality in patients with severe heart failure due to systolic dysfunction. [1] The findings from this trial significantly influenced the treatment guidelines for heart ...

  5. Heart failure - Wikipedia

    en.wikipedia.org/wiki/Heart_failure

    Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood. Although symptoms vary based on which side of the heart is affected, HF typically presents with shortness of breath , excessive fatigue , and bilateral leg swelling . [ 3 ]

  6. Cardiotonic agent - Wikipedia

    en.wikipedia.org/wiki/Cardiotonic_agent

    Digoxin helps alleviate symptoms and reduce hospitalizations related to heart failure, but it does not offer any mortality-reducing benefits. [86] Digoxin may be considered in patients who remain symptomatic despite receiving treatment with a first-line combination of an ACE inhibitor (or ARNI ), a beta-blocker , and a mineralocorticoid ...

  7. Heart failure with preserved ejection fraction - Wikipedia

    en.wikipedia.org/wiki/Heart_failure_with...

    Heart failure with preserved ejection fraction (HFpEF) is a form of heart failure in which the ejection fraction – the percentage of the volume of blood ejected from the left ventricle with each heartbeat divided by the volume of blood when the left ventricle is maximally filled – is normal, defined as greater than 50%; [1] this may be measured by echocardiography or cardiac catheterization.

  8. Ivabradine - Wikipedia

    en.wikipedia.org/wiki/Ivabradine

    Given the selective decrease in rate without loss of contractility, ivabradine may prove efficacious for treatment of congestive heart failure with reduced ejection fraction. Ivabradine binds to HCN4 receptors (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4), utilizing Y506, F509 and I510 residues.

  9. Acute decompensated heart failure - Wikipedia

    en.wikipedia.org/wiki/Acute_decompensated_heart...

    Opioids have traditionally been used in the treatment of the acute pulmonary edema that results from acute decompensated heart failure. A 2006 review, however, found little evidence to support this practice. [17] The National Institutes for Health and Care Excellence (NICE) guidelines do not recommend routinely offering opioids in acute heart ...

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