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  2. Insertion (genetics) - Wikipedia

    en.wikipedia.org/wiki/Insertion_(genetics)

    An illustration of an insertion at chromosome level. In genetics, an insertion (also called an insertion mutation) is the addition of one or more nucleotide base pairs into a DNA sequence. This can often happen in microsatellite regions due to the DNA polymerase slipping. Insertions can be anywhere in size from one base pair incorrectly ...

  3. Insert (molecular biology) - Wikipedia

    en.wikipedia.org/wiki/Insert_(molecular_biology)

    In Molecular biology, an insert is a piece of DNA that is inserted into a larger DNA vector by a recombinant DNA technique, such as ligation or recombination. This allows it to be multiplied, selected, further manipulated or expressed in a host organism .

  4. Genetic engineering techniques - Wikipedia

    en.wikipedia.org/wiki/Genetic_engineering_techniques

    A gene gun uses biolistics to insert DNA into plant tissue. A. tumefaciens attaching itself to a carrot cell. In plants the DNA is often inserted using Agrobacterium-mediated recombination, [27] taking advantage of the Agrobacteriums T-DNA sequence that allows natural insertion of genetic material into plant cells. [28]

  5. Sleeping Beauty transposon system - Wikipedia

    en.wikipedia.org/wiki/Sleeping_Beauty_transposon...

    The Sleeping Beauty transposon system is composed of a Sleeping Beauty (SB) transposase and a transposon that was designed in 1997 to insert specific sequences of DNA into genomes of vertebrate animals. DNA transposons translocate from one DNA site to another in a simple, cut-and-paste manner (Fig. 1).

  6. Intracellular delivery - Wikipedia

    en.wikipedia.org/wiki/Intracellular_delivery

    For a century microinjection has been the dominant method for introducing microscale cargo into cells. A classic example was the transplant of a somatic cell nucleus into a frog egg to demonstrate that nuclei from fully differentiated somatic cells could grow into a new animal when inserted into an egg. [31]

  7. Transposons as a genetic tool - Wikipedia

    en.wikipedia.org/wiki/Transposons_as_a_genetic_tool

    Self ligate the digest (low DNA concentration to ensure self ligation) giving a selection of circular DNA fragments, a few with the E. coli reporter, the plasmid sequences and its flanking DNA. Insert the plasmids into E. coli cells (e.g. by electroporation). Screen plasmids for the E. coli reporter gene.

  8. Gene delivery - Wikipedia

    en.wikipedia.org/wiki/Gene_delivery

    The transferred DNA is piloted to the plant cell nucleus and integrated into the host plants genomic DNA.The plasmid T-DNA is integrated semi-randomly into the genome of the host cell. [ 23 ] By modifying the plasmid to express the gene of interest, researchers can insert their chosen gene stably into the plants genome.

  9. Hydrodynamic delivery - Wikipedia

    en.wikipedia.org/wiki/Hydrodynamic_delivery

    The pressure expands the pores in the cell membrane, forcing the DNA molecules into the parenchyma, or the functional cells of the organ. [1] [5] [2] [4] In the liver, these cells are the hepatocytes. In less than two minutes after the injection, the pressure returns to natural levels, and the pores shrink back, trapping the DNA inside of the ...

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