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Equine protozoal myeloencephalitis in various stages. Equine protozoal myeloencephalitis (EPM) is a disease that affects the central nervous system of horses.It is caused by a protozoal infection that is brought about by the apicomplexan parasites Sarcocystis neurona or Neospora hughesi.
Neospora hughesi is an obligate protozoan apicomplexan parasite that causes myelitis and equine protozoal myeloencephalitis (EPM) in horses, and has only been documented in North America. [1] EPM is a neurological disease from lesions in the spinal cord , brain stem , or brain from parasites such as N. hughesi or Sarcocystis neurona . [ 2 ]
Early clinical signs of EPM include stumbling and frequent interference, which can often be mistaken for lameness of thoracic and/or pelvic limbs in horses. In horses, the disease often progresses gradually and includes clinical signs such as ataxia. In some horses mild clinical signs may herald a rapidly progressive disease course.
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Ponazuril (), sold by Merial, Inc., [1] now part of Boehringer Ingelheim, [2] under the trade name Marquis (15% w/w ponazuril), is a drug currently approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by coccidia Sarcocystis neurona.
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