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The packaging for valsartan includes a warning stating the drug should not be used with the renin inhibitor aliskiren in people with diabetes. It also states the safety of the drug in severe renal impairment has not been established. [7] Valsartan includes a black box warning for fetal toxicity.
The use of valsartan in pregnancy is avoided due to the potential risk of fetal toxicity. [11] The U.S. Food and Drug Administration has a black box warning for valsartan/hydrochlorothiazide use during pregnancy. [2] The use of hydrochlorothiazide is avoided in those with anuria or severe kidney disease. [12]
Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis , normal growth , differentiation , development or behavior.
Environmental toxicants and fetal development is the impact of different toxic substances from the environment on the development of the fetus. This article deals with potential adverse effects of environmental toxicants on the prenatal development of both the embryo or fetus, as well as pregnancy complications. The human embryo or fetus is ...
The problem, he said, is that “war will break these values. “There is an inherent contradiction between the warrior code, how these guys define themselves, what they expect of themselves – to be heroes, the selfless servants who fight for the rest of us – and the impossibility in war of ever living up to those ideals. It cannot be done.
Action in the North Atlantic is a 1943 American war film from Warner Bros. Pictures. It was produced by Jerry Wald, directed by Lloyd Bacon, and adapted by John Howard Lawson from a story by Guy Gilpatric. The film stars Humphrey Bogart and Raymond Massey as officers in the U.S. Merchant Marine during World War II. [2]
Hell and High Water is a 1954 American Technicolor Cold War drama film from 20th Century Fox, directed by Samuel Fuller and starring Richard Widmark, Bella Darvi, and Victor Francen. The film was made to showcase CinemaScope in the confined sets of a submarine , and is not related to the 1933 film by the same name .
An abridged version was released in the United States in 1951 as The Fighting Rats of Tobruk. The film follows three drover friends who enlist in the Australian Army together during World War II. Their story is based on the siege of the Libyan city of Tobruk in North Africa by Rommel's Afrika Korps. The partly Australian defenders held the city ...