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Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, [1] MKKK, [2] M3K, [3] or, MAP3K [4]) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP kinase. Several types of MAPKKK can exist but are mainly characterized by the MAP kinases they activate.
Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene. [5] [6]The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK.
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Shqip; Simple English; Српски / srpski; ... Agon (film) The Albanian; Alexander (2023 film) Alive (2009 film) Amnesty (2011 film) Amsterdam Express; B. Babai (film)
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It was Albania's only film studio under communist rule. [18] [15] Kristaq Dhamo's 1958 film Tana was Kinostudio's first feature-length film and is regarded as the first one in Albanian history. [19] [4] In 1952, Daughters of China (Zhong Hua nu er) became the first Chinese film shown in Albania. [13]
When activated MAPK binds to MKB this causes a conformational change of the DUSP region which activates MKP and activated MKP dephosphorylates MAPK thereby inactivating it.
The Second November (Albanian: Nëntori i dytë) is a 1983 Albanian historical drama film directed by Viktor Gjika. The film is based on the true events leading to the independence of Albania in 1912.