enow.com Web Search

  1. Ads

    related to: small molecule tyrosine kinase inhibitors

Search results

  1. Results from the WOW.Com Content Network
  2. Tyrosine kinase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Tyrosine_kinase_inhibitor

    A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. The proteins are activated by adding a phosphate group to the protein (phosphorylation), a step that TKIs inhibit. TKIs are typically used as ...

  3. VEGFR-2 inhibitor - Wikipedia

    en.wikipedia.org/wiki/VEGFR-2_inhibitor

    Sorafenib is a small molecule inhibitor of many tyrosine kinase receptors such as VEGFR-2. Side effects are in most cases mild to moderate such as rash, hand-foot skin reaction, diarrhea and dermatitis, and occur in about 33-38% patients using sorafenib. Other side effects are mild hypertension, leukopenia and bleeding. Uncommon side effects ...

  4. Axitinib - Wikipedia

    en.wikipedia.org/wiki/Axitinib

    Axitinib, sold under the brand name Inlyta, is a small molecule tyrosine kinase inhibitor developed by Pfizer.It has been shown to significantly inhibit growth of breast cancer in animal models [4] and has shown partial responses in clinical trials with renal cell carcinoma (RCC) [5] and several other tumour types.

  5. Ibrutinib - Wikipedia

    en.wikipedia.org/wiki/Ibrutinib

    Ibrutinib is a potent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). The acrylamide group of ibrutinib forms a covalent bond with the cysteine residue C481 in the BTK active site, leading to sustained inhibition of BTK enzymatic activity. BTK is an important signalling molecule of the B-cell antigen receptor (BCR) pathway, which ...

  6. c-Met inhibitor - Wikipedia

    en.wikipedia.org/wiki/C-Met_inhibitor

    c-Met inhibitors are a class of small molecules that inhibit the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF). These inhibitors may have therapeutic application in the treatment of various types of cancers.

  7. Remibrutinib - Wikipedia

    en.wikipedia.org/wiki/Remibrutinib

    Remibrutinib is a small molecule drug that acts as a Bruton's tyrosine kinase (BTK) inhibitor. It is in development for the treatment of chronic spontaneous urticaria. [1] [2] In November 2023, Novartis announced that the compound "demonstrated clinically meaningful and statistically significant reduction in urticaria activity vs placebo" in a Phase III trial.

  8. Tyrosine kinase - Wikipedia

    en.wikipedia.org/wiki/Tyrosine_kinase

    Gefitinib is a tyrosine kinase inhibitor that targets the epidermal growth factor receptor, inducing favorable outcomes in patients with non-small cell lung cancers. A common, widespread cancer, non-small cell lung cancer is the cause of death in more people than breast, colorectal, and prostate cancer together. [ 15 ]

  9. Mobocertinib - Wikipedia

    en.wikipedia.org/wiki/Mobocertinib

    Mobocertinib is a small molecule tyrosine kinase inhibitor structurally similar to osimertinib (differs only by the presence of an additional isopropyl ester group). [9] Its molecular target is epidermal growth factor receptor (EGFR) bearing mutations in the exon 20 region.

  1. Ads

    related to: small molecule tyrosine kinase inhibitors