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Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or consistency. Lymphadenopathy of an inflammatory type (the most common type) is lymphadenitis , [ 1 ] producing swollen or enlarged lymph nodes.
A lymph node is small, capsulated lymphoid organ that is present along the lymphatic system. It is composed of cortex and medulla. The cortex is also divided into outer cortex and inner cortex (also known as the paracortex).
Lymph node enlargement or swelling is known as lymphadenopathy. [27] Swelling may be due to many causes, including infections , tumors , autoimmune disease , drug reactions , diseases such as amyloidosis and sarcoidosis , or because of lymphoma or leukemia .
The term lymphadenopathy strictly speaking refers to disease of the lymph nodes, [1] though it is often used to describe the enlargement of the lymph nodes. Similarly, the term lymphadenitis refers to inflammation of a lymph node, but often it is used as a synonym of lymphadenopathy. Cervical lymphadenopathy is a sign or a symptom, not a diagnosis.
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Generalized lymphadenopathy is swollen lymph glands in many areas of the body. [ 1 ] Usually this is in response to a body-wide infectious disease such as influenza and will go away once the person has recovered, but sometimes it can persist long-term, even when there is no obvious cause of disease.
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In mammals, including humans, the lymphatic system is composed of a network of thin vessels that branch, like blood vessels, into tissues throughout the body.Lymphatic vessels carry lymph, a colorless, watery fluid originating from interstitial fluid (fluid in the tissues) which is squeezed out of the blood vessels.