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Clearance, half-life and volume of distribution. There is an important relationship between clearance, elimination half-life and distribution volume.
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
The plasma half-life or half life of elimination is the time required to eliminate 50% of the absorbed dose of a drug from an organism. Or put another way, the time that it takes for the plasma concentration to fall by half from its maximum levels.
Clearance: The volume of plasma cleared of the drug per unit time. / = 0.38 L/h ... steady state is reached after 3 to 5 times its half-life.
It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC. This is an example of a PK/PD model, which combines pharmacokinetics and pharmacodynamics. [13]
In pharmacology, the volume of distribution (V D, also known as apparent volume of distribution, literally, volume of dilution [1]) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. [2]
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t 1/2 is the half-life time of the drug, which is the time needed for the plasma drug concentration to drop to its half Therefore, the amount of drug present in the body at time t A t {\displaystyle A_{t}} is;