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People who rely on Qualaquin, also known as quinine sulfate, to combat their nighttime leg cramps are putting their lives at risk, warned the Food and Drug Administration. The federal agency ...
Quinine is a medication used to treat malaria and babesiosis. [5] This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available. [5] [6] While sometimes used for nocturnal leg cramps, quinine is not recommended for this purpose due to the risk of serious side effects. [5]
Besides being painful, a nocturnal leg cramp can cause much distress and anxiety. [14] The precise cause of these cramps is unclear. Potential contributing factors include dehydration , low levels of certain minerals ( magnesium , potassium , calcium , and sodium , although the evidence has been mixed), [ 15 ] [ 16 ] [ 17 ] and reduced blood ...
Hypersensitivity to quinine, mefloquine, quinidine, or dextromethorphan/quinidine with a history of thrombocytopenia, hepatitis, bone marrow depression or lupus-like syndrome induced by these drugs; QT interval, prolonged or congenital long QT syndrome or a history suggesting torsades de pointes
In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm [8] (83 mg per liter), while the daily therapeutic dose of quinine is in the range of 500–1000 mg, [9] and 10 mg/kg every eight hours for effective malaria prevention (2,100 mg daily for a 70-kilogram (150 lb) adult). [10]
John S. Sappington (1776-1856) was an American physician known for developing a quinine pill to treat malarial and other fever diseases in the Missouri and Mississippi valleys, where the disease was widespread. He later used the pill to prevent malaria.
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