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The pancreas is a major organ functioning as an accessory digestive gland in the digestive system. It is both an endocrine gland and an exocrine gland . [ 28 ] The endocrine part secretes insulin when the blood sugar becomes high; insulin moves glucose from the blood into the muscles and other tissues for use as energy.
The digestive system has a complex system of motility and secretion regulation which is vital for proper function. This task is accomplished via a system of long reflexes from the central nervous system (CNS), short reflexes from the enteric nervous system (ENS) and reflexes from GI peptides working in harmony with each other. [4]
Secretin primarily functions to neutralize the pH in the duodenum, allowing digestive enzymes from the pancreas (e.g., pancreatic amylase and pancreatic lipase) to function optimally. [24] Secretin targets the pancreas; pancreatic centroacinar cells have secretin receptors in their plasma membrane.
Secretion of the hormone glucose-dependent insulinotropic peptide, which stimulates the release of insulin M cells: Intestinal glands of duodenum and jejunum: Secretion of the hormone motilin, which accelerates gastric emptying, stimulates intestinal peristalsis, and stimulates the production of pepsin S cells: Intestinal glands
Relaxes smooth muscle of gut, blood vessels, and genitourinary system; increases water and electrolyte secretion from pancreas and gut; releases hormones from pancreas, gut, and hypothalamus Glucose-dependent insulinotropic: 4976: 42: Duodenum and jejunum
Composed of simple columnar epithelium its main functions are absorption, and secretion. Useful substances are absorbed into the body, and the entry of harmful substances is restricted. Secretions include mucins, and peptides. Absorptive cells in the small intestine are known as enterocytes, and in the colon they are known as colonocytes.
A fourth phase of acid secretion is known as the basal state which occurs in the times between meals (interdigestive phase). The level of acid secretion during these times is regulated by body weight, individual, number of parietal cells, and time of day. Acid secretion is lowest in the morning before awakening and highest at night. [2]
The myenteric plexus (or Auerbach's plexus) provides motor innervation to both layers of the muscular layer of the gut, having both parasympathetic and sympathetic input (although present ganglion cell bodies belong to parasympathetic innervation, fibers from sympathetic innervation also reach the plexus), whereas the submucous plexus provides secretomotor innervation to the mucosa nearest the ...