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Selexipag, sold under the brand name Uptravi, is a medication developed by Actelion for the treatment of pulmonary arterial hypertension (PAH). [3] [4] Selexipag and its active metabolite, ACT-333679 (or MRE-269, the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. [5]
Sitaxentan is a small molecule that blocks the action of endothelin (ET) on the endothelin-A (ET A) receptor selectively (by a factor of 6000 compared with the ET B). [3] It is a sulfonamide class endothelin receptor antagonist (ERA) and is undergoing Food and Drug Administration (FDA) review for treating pulmonary hypertension.
Milrinone is a phosphodiesterase-3 inhibitor. This drug inhibits the action of phosphodiesterase-3 and thus prevents degradation of cAMP. Normally, cAMP causes increased activation of protein kinase A (PKA). PKA is an enzyme that phosphorylates many elements of the contractile machinery within the heart cell. In the short term this leads to an ...
A host of newly approved drugs for pulmonary arterial hypertension, or PAH, means 2014 will be a battleground for market share in the multibillion-dollar indication. Among those competing will be ...
every 2 hours quaque secunda hora q.4.h., q4h every 4 hours quaque quarta hora q.6.h., q6h every 6 hours quaque sexta hora q.8.h., q8h every 8 hours quaque octava hora q.a.m., qAM, qam every morning: quaque ante meridiem q.d., qd every day / daily quaque die q.h.s., qhs every night at bedtime quaque hora somni q.d.s, qds, QDS 4 times a day
Those living with PAH should work closely with their healthcare team to manage their disease. Support can be found by calling the American Lung Association HelpLine at 1-800-586-4872 and pressing 2.
Macitentan, sold under the brand name Opsumit, is an endothelin receptor antagonist developed by Actelion and approved for the treatment of pulmonary arterial hypertension (PAH). [5] Macitentan is a dual endothelin receptor antagonist, meaning that it acts as an antagonist of two endothelin (ET) receptor subtypes, ET A and ET B . [ 5 ]
If America were to stay with standard time year-round, then sunshine during warm-weather months would hit bedroom curtains at unaccustomed early hours, perhaps between 4:30 a.m. and 5:30 a.m.
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