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Triiodothyronine, also known as T 3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate. [1] Production of T 3 and its prohormone thyroxine (T 4) is activated by thyroid-stimulating hormone (TSH), which is released from the anterior ...
3,3'-Diiodothyronine, also known as 3,3'-T 2, is a metabolite of thyroid hormone. It is formed from the breakdown of triiodothyronine . Levels can be affected in certain disease states.
Thyroid hormones lead to heat generation in humans. However, the thyronamines function via some unknown mechanism to inhibit neuronal activity; this plays an important role in the hibernation cycles of mammals and the moulting behaviour of birds. One effect of administering the thyronamines is a severe drop in body temperature.
The pituitary gland secretes thyrotropin (TSH; Thyroid Stimulating Hormone) that stimulates the thyroid to secrete thyroxine (T4) and, to a lesser degree, triiodothyronine (T3). The major portion of T3, however, is produced in peripheral organs, e.g. liver, adipose tissue, glia and skeletal muscle by deiodination from
Thyroid follicular cells form a simple cuboidal epithelium and are arranged in spherical thyroid follicles surrounding a fluid filled space known as the colloid. The interior space formed by the follicular cells is known as the follicular lumen .
The less T3 and T4 your body produces, the less your body burns calories for fuel which can lead to weight gain, per a study in the International journal of general medicine.
Three related isoforms, deiodinase type I, II, and III, contribute to activation and inactivation of the initially released hormone precursor T 4 into T 3 (triiodothyronine) or rT 3 (reverse triiodothyronine) in target cells. The enzymes catalyze a reductive elimination of iodine (the different isoforms attack different thyronine positions ...
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