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Thereafter, the otic cup closes off, creating the otic vesicle. Once formed, the otic vesicle will reside next to the neural tube medially, and on the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across ...
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Only the epidermis in the head is competent to respond to the signal from the optic vesicles. Both the optic vesicle and the head epidermis are required for eye development. The competence of the head epidermis to respond to the optic vesicle signals comes from the expression of Pax6 in the epidermis. Pax6 is necessary and sufficient for eye ...
Around the 28th day, parts of the otic vesicle begin to form the vestibulocochlear nerve. [20] [22] These form bipolar neurons, which supply sensation to parts of the inner ear (namely the sensory parts of the semicircular canals, macular of the utricle and saccule, and organ of Corti). [20] Around the 33rd day, the vesicles begin to differentiate.
The otic placode forms the otic pit and the otic vesicle, giving rise eventually to organs of hearing and equilibrium. The epibranchial or epipharyngeal placodes generate the distal portion of the ganglia of cranial nerves VII, IX and X: [3]
The cochlear duct develops from the ventral otic vesicle (otocyst). [3] It grows slightly flattened between the middle and outside of the body. [3] This development may be regulated by the genes EYA1, SIX1, GATA3, and TBX1. [3] The organ of Corti develops inside the cochlear duct. [4]
The eyes begin to develop as a pair of diverticula (pouches) from the lateral aspects of the forebrain.These diverticula make their appearance before the closure of the anterior end of the neural tube; [1] [2] after the closure of the tube around the 4th week of development, they are known as the optic vesicles.