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The choice between the drugs is to a large degree determined by the characteristics of the patient being prescribed for, the drugs' side effects, and cost. Most drugs have other uses; sometimes the presence of other symptoms can warrant the use of one particular antihypertensive. Examples include: Age can affect the choice of medications.
Metoprolol was first made in 1969, patented in 1970, and approved for medical use in 1978. [11] [12] [13] It is on the World Health Organization's List of Essential Medicines. [14] It is available as a generic medication. [4] In 2022, it was the sixth most commonly prescribed medication in the United States, with more than 65 million prescriptions.
The neuropsychiatric side effects of some beta blockers (e.g. sleep disruption, insomnia) may be due to this effect. [99] Some pre-clinical and clinical research suggests that some beta blockers may be beneficial for cancer treatment. [100] [101] However, other studies do not show a correlation between cancer survival and beta blocker usage.
Cardiovascular risk factors such as type 2 diabetes, obesity, high blood pressure, and smoking are already known to significantly increase the likelihood of developing dementia.
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Modified-release dosage and its variants are mechanisms used in tablets (pills) and capsules to dissolve a drug over time in order to be released more slowly and steadily into the bloodstream, while having the advantage of being taken at less frequent intervals than immediate-release (IR) formulations of the same drug.
President-elect Trump's adviser on government efficiency, Elon Musk, called for eliminating the Consumer Financial Protection Bureau.
The first-dose phenomenon is a sudden and severe fall in blood pressure that can occur when changing from a lying to a standing position the first time that an alpha blocker drug is used [1] or when resuming the drug after many months off. [2]