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Cholinergic urticaria may significantly impair quality of life, especially in relation to normal day to day activities. It is caused by an overreaction of the immune system to the release of histamine, mast cells, and other chemicals in response to the small nerve fibers throughout the body due to the increase in body temperature being allergic ...
Cholinergic urticaria (CU) is one of the physical urticaria (hives) which is provoked during sweating events such as exercise, bathing, staying in a heated environment, or emotional stress. The hives produced are typically smaller than classic hives and are generally shorter-lasting.
Hives, also known as urticaria, is a kind of skin rash with red and/or flesh-colored, raised, itchy bumps. [1] Hives may burn or sting. [2] The patches of rash may appear on different body parts, [2] with variable duration from minutes to days, and do not leave any long-lasting skin change. [2]
Dermatographic urticaria is sometimes called "skin writing", as it is possible to mark deliberate patterns onto the skin. The condition manifests as an allergic-like reaction, causing a warm red wheal to appear on the skin. As it is often the result of scratches, involving contact with other materials, it can be confused with an allergic ...
Cholinergic urticaria or sharp pain over the entire body induced by elevated body temperature was reported in 32 cases (50%). Of 28 cases tested, 12 (43%) displayed elevated serum IgE levels. Skin biopsy was performed in 53 cases, with normal findings in 20 cases (38%), and cellular infiltrates in sweat glands or ducts in 23 cases (43%).
However, the understanding of urticaria as an autoimmune condition is a relatively recent development in medical history. [14] The term autoimmune urticaria refers to a subset of chronic spontaneous urticaria (CSU) cases where the immune system appears to play a significant role. This understanding began to evolve in the mid to late 20th ...
Cholinergic agents are compounds which mimic the action of acetylcholine and/or butyrylcholine. [1] In general, the word "choline" describes the various quaternary ...
Chronic spontaneous urticaria, despite its cause being unknown, is linked to a higher prevalence of autoimmune diseases, and is often worsened by triggers like stress, infections, certain foods, or nonsteroidal anti-inflammatory drugs. The hives and angioedema seen in CSU is thought to be linked to the degranulation of skin mast cells.