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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
It is a prodrug of tolvaptan, [1] [2] formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration. It was developed by Otsuka Pharmaceutical Co. and was approved for use in Japan in 2022. [3]
Tolvaptan is a racemic small molecule drug (Molecular Weight of 448.9 g.mol-1) and is a lipophilic drug, is essentially insoluble in water, and has fair oral absorption (>40% bioavailable). Tolvaptan hsa a plasma half-life of around 12 hours, a volume of distribution of 3L/kg, and has high plasma protein binding at 99%.
More and more people are talking about polyphasic sleep patterns. But a sleep doctor explains why polyphasic sleep is so unhealthy for humans.
People who bought the recalled holiday candy are urged to call Gardners corporate office for a replacement at 1-800-242-2639, Monday through Friday from 7:30 a.m. to 4 p.m. Eastern time.
A Texas teen is accused of killing a classmate’s show goat by force-feeding it pesticide. Aubrey Vanlandingham, 17, is charged with cruelty to livestock animals, a felony, according to court ...
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