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  2. Peptide synthesis - Wikipedia

    en.wikipedia.org/wiki/Peptide_synthesis

    In organic chemistry, peptide synthesis is the production of peptides, compounds where multiple amino acids are linked via amide bonds, also known as peptide bonds. Peptides are chemically synthesized by the condensation reaction of the carboxyl group of one amino acid to the amino group of another.

  3. Robert Bruce Merrifield - Wikipedia

    en.wikipedia.org/wiki/Robert_Bruce_Merrifield

    Robert Bruce Merrifield (July 15, 1921 – May 14, 2006) was an American biochemist who won the Nobel Prize in Chemistry in 1984 for the invention of solid phase peptide synthesis. [ 2 ] Early life

  4. File:Peptide Synthesis.svg - Wikipedia

    en.wikipedia.org/wiki/File:Peptide_Synthesis.svg

    You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made.

  5. Combinatorial chemistry - Wikipedia

    en.wikipedia.org/wiki/Combinatorial_chemistry

    Combinatorial split-mix (split and pool) synthesis [12] [13] is based on the solid-phase synthesis developed by Merrifield. [14] If a combinatorial peptide library is synthesized using 20 amino acids (or other kinds of building blocks) the bead form solid support is divided into 20 equal portions. This is followed by coupling a different amino ...

  6. Solid-phase synthesis - Wikipedia

    en.wikipedia.org/wiki/Solid-phase_synthesis

    The process was originally developed in the 1950s and 1960s by Robert Bruce Merrifield in order to synthesise peptide chains, [4] and which was the basis for his 1984 Nobel Prize in Chemistry. [5] In the basic method of solid-phase synthesis, building blocks that have two functional groups are used.

  7. Svetlana Mojsov - Wikipedia

    en.wikipedia.org/wiki/Svetlana_Mojsov

    Mojsov was born in Skopje, Macedonia, ex-Yugoslavia and did her undergraduate degree in physical chemistry in Belgrade.She joined the graduate program at the Rockefeller University in 1972, where she worked alongside Robert Bruce Merrifield (1984 Nobel Prize in Chemistry) on the synthesis of peptides. [1]

  8. Merrifield resin - Wikipedia

    en.wikipedia.org/wiki/Merrifield_resin

    Merrifield Resin is a cross-linked polystyrene resin that carries a chloromethyl functional group. Merrifield resin is named after its inventor, Robert Bruce Merrifield (1984 winner of the Nobel Prize in Chemistry), and used in solid-phase synthesis. The material is typically available as white beads.

  9. Protecting group - Wikipedia

    en.wikipedia.org/wiki/Protecting_group

    The technique was introduced in the field of peptide synthesis by Robert Bruce Merrifield in 1977. [111] For peptide synthesis via automated machine, the orthogonality of the Fmoc group (basic cleavage), the tert‑butyl group (acidic cleavage) and diverse protecting groups for functional groups on the amino acid side-chains are used. [112]