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After separation from glucose, galactose travels to the liver for conversion to glucose. [12] Galactokinase uses one molecule of ATP to phosphorylate galactose. [ 2 ] The phosphorylated galactose is then converted to glucose-1-phosphate, and then eventually glucose-6-phosphate, which can be broken down in glycolysis.
Galactose (/ ɡ ə ˈ l æ k t oʊ s /, galacto-+ -ose, "milk sugar"), sometimes abbreviated Gal, is a monosaccharide sugar that is about as sweet as glucose, and about 65% as sweet as sucrose. [2] It is an aldohexose and a C-4 epimer of glucose. [3] A galactose molecule linked with a glucose molecule forms a lactose molecule.
Galactosemia, the inability to metabolize galactose in liver cells, is the most common monogenic disorder of carbohydrate metabolism, affecting 1 in every 55,000 newborns. [2] When galactose in the body is not broken down, it accumulates in tissues. The most common signs are failure to thrive, hepatic insufficiency, cataracts and developmental ...
Intermediates and enzymes in the Leloir pathway of galactose metabolism [5] In the first step, galactose mutarotase facilitates the conversion of β-D-galactose to α-D-galactose since this is the active form in the pathway. Next, α-D-galactose is phosphorylated by galactokinase to galactose 1-phosphate.
β-Galactosidase is an exoglycosidase which hydrolyzes the β-glycosidic bond formed between a galactose and its organic moiety. It may also cleave fucosides and arabinosides but at a much lower rate. It is an essential enzyme in the human body. Deficiencies in the protein can result in galactosialidosis or Morquio B syndrome.
Galactooligosaccharides (GOS), which also occur naturally, consist of short chains of galactose molecules. Human milk is an example of this and contains oligosaccharides, known as human milk oligosaccharides (HMOs), which are derived from lactose. [21] [22] These oligosaccharides have biological function in the development of the gut flora of ...
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In humans it is the terminal carbohydrate forming the antigen of blood group A. [1]. It is typically the first monosaccharide that connects serine or threonine in particular forms of protein O-glycosylation.