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The airways and lungs receive continuous first-pass exposure to non-toxic and irritant or toxic gases via inhalation. Irritant gases are those that, on inhalation, dissolve in the water of the respiratory tract mucosa and provoke an inflammatory response, usually from the release of acidic or alkaline radicals.
Nitrogen dioxide inhalation can result in short and long-term morbidity or death depending on the extent of exposure and inhaled concentration and the exposure time. Illness resulting from acute exposure is usually not fatal although some exposure may cause bronchiolitis obliterans, pulmonary edema as well as rapid asphyxiation. [40]
Acute chlorine gas poisoning primarily affects the respiratory system, causing difficulty breathing, cough, irritation of the eyes, nose, and throat, and sometimes skin irritation. Higher exposures can lead to severe lung damage, such as toxic pneumonitis or pulmonary edema, with concentrations around 400 ppm and beyond
Smoke inhalation is the breathing in of harmful fumes (produced as by-products of combusting substances) through the respiratory tract. [1] This can cause smoke inhalation injury (subtype of acute inhalation injury) which is damage to the respiratory tract caused by chemical and/or heat exposure, as well as possible systemic toxicity after smoke inhalation.
The following tests help determine how severely the lungs are affected: Blood gases (measurement of how much oxygen and carbon dioxide are in your blood) CT scan of chest; Lung function studies (tests to measure breathing and how well the lungs are functioning) X-ray of the chest; Swallowing studies to check if stomach acid is the cause of ...
Inhalation is a major route of exposure that occurs when an individual breathes in polluted air which enters the respiratory tract. Identification of the pollutant uptake by the respiratory system can determine how the resulting exposure contributes to the dose .
Inhalation of toxic materials can also cause serious injury to the respiratory tract. [21] Severe trauma to the chest can cause damage to the lungs, including pulmonary contusions, accumulation of blood, or a collapsed lung. The inflammation response to a lung injury can cause acute
Acute toxicity describes the adverse effects of a substance that result either from a single exposure [1] or from multiple exposures in a short period of time (usually less than 24 hours). [ 2 ] To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance.