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Thymic epithelial cells (TECs) are specialized cells with high degree of anatomic, phenotypic and functional heterogeneity that are located in the outer layer (epithelium) of the thymic stroma. The thymus , as a primary lymphoid organ , mediates T cell development and maturation.
Epithelial cells in the medulla and dendritic cells in the thymus express major proteins from elsewhere in the body. [13] The gene that stimulates this is AIRE. [12] [13] Thymocytes that react strongly to self antigens do not survive, and die by apoptosis. [12] [13] Some CD4 positive T cells exposed to self antigens persist as T regulatory ...
Cortical thymic epithelial cells (cTECs) form unique parenchyma cell population of the thymus which critically contribute to the development of T cells. Thymus tissue is compartmentalized into cortex and medulla and each of these two compartments comprises its specific thymic epithelial cell subset. cTECs reside in the outer part- cortex, which ...
Hassall's corpuscles (also known as thymic bodies) are structures found in the medulla of the human thymus, formed from eosinophilic type VI thymic epithelial cells arranged concentrically. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells.
The barrier also prevents the immature T cells from contacting foreign antigens (since contact with antigens at this stage will cause the T cells to die by apoptosis). The barrier is formed by the continuous blood capillaries in the thymic cortex, reinforced by type 1 epithelial reticular cells (sometimes called thymic epithelial cells ) and ...
Thymus stromal cells are subsets of specialized cells located in different areas of the thymus. [1] They include all non-T-lineage cells, such as thymic epithelial cells (TECs), endothelial cells, mesenchymal cells, dendritic cells, and B lymphocytes, and provide signals essential for thymocyte development and the homeostasis of the thymic stroma.
The brain may contain higher -- and more significant -- amounts of microplastics than other organs in the body, according to a new study. Researchers from the University of New Mexico Health ...
In 1989, two scientific groups came up with the hypothesis that the thymus expresses genes which are in the periphery, strictly expressed by specific tissues (e.g.: Insulin produced by β cells of the pancreas) to subsequently present these so-called "tissue-restricted antigens" (TRAs) from almost all parts of the body to developing T cells in order to test which TCRs recognize self-tissues ...