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Also, amino acid side chain affinity for water was measured using vapor phases. [14] Vapor phases represent the simplest non polar phases, because it has no interaction with the solute. [ 18 ] The hydration potential and its correlation to the appearance of amino acids on the surface of proteins was studied by Wolfenden.
The polar, uncharged amino acids serine (Ser, S), threonine (Thr, T), asparagine (Asn, N) and glutamine (Gln, Q) readily form hydrogen bonds with water and other amino acids. [32] They do not ionize in normal conditions, a prominent exception being the catalytic serine in serine proteases .
AAindex is a database of amino acid indices, amino acid mutation matrices, and pair-wise contact potentials. [ 1 ] [ 2 ] The data represent various physicochemical and biochemical properties of amino acids and pairs of amino acids.
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For instance, if a stretch of about 20 amino acids shows positive for hydrophobicity, these amino acids may be part of alpha-helix spanning across a lipid bilayer, which is composed of hydrophobic fatty acids. On the converse, amino acids with high hydrophilicity indicate that these residues are in contact with solvent, or water, and that they ...
A conservative replacement (also called a conservative mutation or a conservative substitution or a homologous replacement) is an amino acid replacement in a protein that changes a given amino acid to a different amino acid with similar biochemical properties (e.g. charge, hydrophobicity and size). [1] [2]
The pH-dependence of the activity displayed by enzymes and the pH-dependence of protein stability, for example, are properties that are determined by the pK a values of amino acid side chains. The p K a values of an amino acid side chain in solution is typically inferred from the p K a values of model compounds (compounds that are similar to ...
Chemical formula: C 5 H 10 N 2 O 3 Molar mass: 146.15 g·mol −1 Systematic name: (2S)-2-amino-4-carbamoyl-butanoic acid Abbreviations: Q, Gln Synonyms: {γ/+/-/D/L}-Glutamine 2-amino-4-carbamoylbutanoic acid {L-/D-}2-aminoglutaramic acid AI3-32686 C00303 Cebrogen G107 Glumin Glutamic acid {5-/γ-} amide {L-/D-}glutamid Miglu-P NSC 97925 NSC27421