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Doxercalciferol (or 1-hydroxyergocalciferol, trade name Hectorol) is drug for secondary hyperparathyroidism and metabolic bone disease. [1] It is a synthetic analog of ergocalciferol (vitamin D 2). It suppresses parathyroid synthesis and secretion. [2] Doxercalciferol is the vitamin D 2 analogue of alfacalcidol. [3]
The natural, active form of vitamin D is calcitriol (1,25-dihydroxycholecalciferol). This molecule and other naturally occurring forms of vitamin D, including its precursors and metabolites, have been modified to synthesize pharmaceuticals with potentially greater, or selective, therapeutic actions. [1] [2] [3] [4]
Shingles, also known as herpes zoster or zona, [6] is a viral disease characterized by a painful skin rash with blisters in a localized area. [2] [7] Typically the rash occurs in a single, wide mark either on the left or right side of the body or face. [1] Two to four days before the rash occurs there may be tingling or local pain in the area.
Calcitriol is also produced outside the kidney in small amounts by many other tissues including placenta and activated macrophages. [31] When the drug alfacalcidol is used, 25-hydroxylation in the liver produces calcitriol as the active metabolite. This will produce greater effects than other vitamin D precursors in patients with kidney disease ...
Temporary side effects from the Shingrix shots are likely and can be severe enough in one out of six people to affect normal daily activities for up to three days. [18] Mild to moderate pain at the injection site is common, and some may have redness or swelling. [18] Side effects include fatigue, muscle pain, headache, shivering, fever, and ...
Image credits: demimoore In addition, the usage of Ozempic has dominated so much of Hollywood that “celebrity and high profile clients” are hosting GLP-1 “parties” of sorts where nurse ...
Paricalcitol (chemically it is 19-nor-1,25-(OH) 2-vitamin D 2.Marketed by Abbott Laboratories under the trade name Zemplar) is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic kidney failure.
Side effects are suspected and the drug is sometimes discontinued if the patient complains of recurrent episodes of sore throat. Another life-threatening side effect is sudden, severe, fulminant liver failure resulting in death or the need for a liver transplantation, which occurs in up to 1 in 10,000 people taking propylthiouracil.