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The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6] It is a member of the tumor necrosis factor superfamily, a family of transmembrane proteins that are cytokines, chemical messengers of the immune system. [7]
In humans, there are 29 known family members of the TNF receptor superfamily. [6] [7] Historically, the family members have been numerically classified as TNFRSF#, where # denotes the member number, sometimes followed a letter. [2] Some newer additions to the TNF family remain unnumbered, however, such as the TNF receptor superfamily member ...
Lymphotoxin-alpha (LT-α) formerly known as tumor necrosis factor-beta (TNF-β) [5] [6] is a protein that in humans is encoded by the LTA gene. [7] [8] Belonging to the hematopoietic cell line, LT-α exhibits anti-proliferative activity and causes the cellular destruction of tumor cell lines. [7]
[2] [3] [5] LT-αβ, which is produced by activated Type 1 T helper cells (T h 1), CD8+ T cells, and natural killer (NK) cells, is known to have a major role in the normal development of Peyer's patches. [6] [7] Studies have found that mice with an inactivated LT-α gene (LTA) lack developed Peyer's patches and lymph nodes. In addition, LT-αβ ...
The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation.
21942 Ensembl ENSG00000049249 ENSMUSG00000028965 UniProt Q07011 P20334 RefSeq (mRNA) NM_001561 NM_001077508 NM_001077509 NM_011612 RefSeq (protein) NP_001552 NP_001070976 NP_001070977 NP_035742 Location (UCSC) Chr 1: 7.92 – 7.94 Mb Chr 4: 151 – 151.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD137, a member of the tumor necrosis factor (TNF) receptor family, is a type 1 ...
21930 Ensembl ENSG00000123610 ENSMUSG00000053475 UniProt P98066 O08859 RefSeq (mRNA) NM_007115 NM_009398 RefSeq (protein) NP_009046 NP_033424 Location (UCSC) Chr 2: 151.36 – 151.38 Mb Chr 2: 51.93 – 51.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor-inducible gene 6 protein also known as TNF-stimulated gene 6 protein or TSG-6 is a protein that in humans ...